MFELE NTSA Jeanine, KAZADI KASHISHI Théodore, NTUMBA KANKOLONGO Josephine, TABA KALULU Muzele, TSHIONGO MUAMBA Christian*

Malaria is one of the most frequent infectious diseases in the world with an annual mortality rate of more than one million people per year. The parasite responsible, Plasmodium, is becoming increasingly resistant to the drugs currently in use. Thus, Strophanthus hispidus DC, a medicinal plant widely used in traditional medicine in West Africa and in the Democratic Republic of Congo, was chosen to evaluate the anti-malarial activity of different extracts from the bark of its roots on malaria-infected blood using the microplate method. In vitro evaluation of the antiplasmodial activity of crude extracts (petroleum ether, dichloromethane, ethyl acetate, ethanolic, aqueous and methanolic) showed good antiplasmodial activity, with IC50 of 6.25 μg/mL, 6.01 μg/mL, 3.10 μg/mL, 3.12 μg/mL, 3.02 μg/mL and 0.39 μg/mL, respectively. This activity could be due to the presence of secondary metabolites found in various extracts including polyphenols and flavonoids. The dichloromethane and ethyl acetate extracts were separated by thin layer chromatography, each of which yielded two fractions that also showed very good antimalarial activities with IC50 values of 0.78 μg/mL, 1.02 μg/mL, 1.56 μg/mL, 12.20 μg/mL for the dichloromethane 1, dichloromethane 2, ethyl acetate 1 and ethyl acetate 2 fractions respectively. These results justify the traditional use of S. hispidus DC. against malaria. Télécharger l'article